https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 A novel structural framework for α1A/D-adrenoceptor selective antagonists identified using subtype selective pharmacophores https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14134 1D- subtype compared to α1A- and α1B-ARs. 9 out of 12 of the tested compounds displayed affinity at the α1A and α1D -AR subtypes and 6 displayed affinity at all three α₁-AR subtypes, no α1B-AR selective compounds were identified. 8 of the 9 compounds with α₁-AR affinity were antagonists and one compound displayed partial agonist characteristics. This virtual screening has successfully identified an α1A/D-AR selective antagonist, with low µM affinity with a novel structural scaffold of a an isoquinoline fused three-ring system and good lead-like qualities ideal for further drug development.]]> Wed 11 Apr 2018 14:43:43 AEST ]]> Exploring or avoiding novel food resources? the novelty conflict in an invasive bird https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15694 Wed 11 Apr 2018 11:06:55 AEST ]]>